Tesamorelin Nasal Spray

Tesamorelin nasal spray is a research-based peptide studied for its growth hormone-releasing hormone (GHRH) effects [1]. The nasal spray form comes inside the bottle and may offer quick delivery of tesamorelin.

What Is Tesamorelin Nasal Spray?

Tesamorelin nasal spray is used to offer the effects of tesamorelin peptide to research subjects. Tesamorelin is a synthetic peptide that consists of 44 amino acids with the addition of a trans-3-hexenoic acid group [1].

One study has found that Tesamorelin is the same hormone that may be released from the hypothalamus gland in the brain of research subjects. Another study has discussed its potential in the treatment of lipodystrophy (reduction of excessive fat)  in the stomach area, particularly in HIV subjects [2,4].

Working Mechanism:

In different research settings, it has been observed that tesamorelin works by stimulating the production and release of Growth Hormone (GH). This ultimately increases levels of insulin-like growth factor (IGF-1) [2, 5]. Besides, the released GH  interacts with receptors such as the liver, fat cells, muscles, and bones to promote fat loss.

Research on Tesamorelin has described that this synthetic version of the peptide may be more potent and stable than the original peptide found in research subjects.  It is also said that Tesamorelin may be less likely to break down by the enzyme dipeptidyl aminopeptidase, which affects human GHRH.

Potential Benefits Of Tesamorelin Nasal Spray

Tesamorelin nasal spray may have the following benefits:

Non-Invasive Delivery:

Tesamorelin nasal spray offers a non-invasive method for administering medication to research subjects. It is said that the nasal spray form may bypass the digestive system and absorb quickly in the bloodstream to show its results.

More Stable:

The nasal spray form of tesamorelin may provide more stable drug absorption, ensuring consistent bioavailability.

May Reduce Visceral Fat:

A study on Tesamorelin has shown its impact on visceral fat. Visceral fat is accumulated in the internal organs. It’s a harmful fat and its reduction may improve the subject’s body composition. By releasing more GH from the pituitary gland, tesamorelin may help break down the stored fat,   particularly in the abdominal region. [3,4,5]

May Improve Lipid Profile:

Lower visceral fat may improve lipid metabolism. Studies have shown that Tesamorelin may lower triglyceride levels and enhance cholesterol ratios by increasing HDL (“good”) cholesterol and reducing LDL (“bad”) cholesterol. This may lower the risk of cardiovascular diseases.

May Promote Better Metabolic Health:

Tesamorelin may have the potential to improve insulin sensitivity and glucose metabolism. It does so by reducing the visceral fat and promoting lean muscle mass. Both of which may help reduce insulin resistance. [5,6]

As a result, individuals may experience more stable blood sugar levels and improved metabolic function.